SynepinTMINCI named cosmeceutical / cosmetic ingredient (SE208), is a low molecular-weight tripeptide derived from epidermal growth factor(EGF) that stimulates cell growth, proliferation and differentiation by binding to its receptor EGFR.





  1. The activation of EGFR (Epidermal Growth Factor Receptor)


    Synepin treatment induced the interaction between Gab1 and Shp2 that was induced by the activation of EGFR.





  2. The promotion of the proliferation of the Cultured Human Keratinocyte cell line, HaCaT.


    Synepin tripeptide significantly promoted the proliferation of human keratinocyte HaCaT cell line.




  3. The activation of ERK and Akt


    Synepin treatment induced the activation of ERK1/2 and Akt in a dose-dependent manner.



  4. The promotion of neo-angiogenesis in vitro

         Syndermin treatment significantly increased the tubular formation of the human umbilical vein endothelial cells in vitro.







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