TenefrinTM tripeptide inhibits TNF (tumor-necrosis factor- α), another inflammatory factor, leading to skin soothing or anti-photo aging with its anti- inflammation reaction.

1. In vivo transendothelial migration assay of mouse monocytes.


- PMA-induced ear inflammation in mice stimulates the extravasation of monocytes from blood vessels into the inflamed tissues. Tenefrin significantly reduced the monocyte extravasation.

2. Expression of MMP-1 in human fibroblasts.


- Tenefrin treatment dose-dependently suppressed the expression of MMP-1 which was induced by inflammatory cytokine.







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