NF-kB is a transcription factor involved in the proinflammatory responses causing the skin aging and inflammation. EnfibinTM tripeptide inhibits NF-kB activity, thereby functions as cosmetic ingredients for skin soothing, anti-inflammation, and anti-photo-aging.
Inhibition of the activation of NF-κB in the mouse macrophage RAW264.7.
- Enfibin treatment suppressed the LPS-induced activation of the nuclear factor NF-κB.
2. The expression of type I procollagen and MMP-1 in human dermal fibroblast
- Enfibin treatment does-dependently restored the UV-induced degradation of type I procollagenand reduced MMP-1 expression which was upregulated by UV stimulation.